What is the meaning of irritation?

noun

• The psychological state of being irritated or annoyed.
  • synonyms: annoyance, vexation, botheration
• A sudden outburst of anger.
  • usage: "his temper sparked like damp firewood"
  • synonyms: pique, temper
• Pathology) abnormal sensitivity to stimulation. (
  • usage: "any food produced irritation of the stomach"
• The neural or electrical arousal of an organ or muscle or gland.
  • synonyms: excitation, innervation
• An uncomfortable feeling of mental painfulness or distress.
  • synonyms: discomfort, soreness
• Unfriendly behavior that causes anger or resentment.
  • synonyms: aggravation, provocation
• The act of troubling or annoying someone.
  • synonyms: annoyance, annoying, vexation