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lemon(noun, defeat, blow, failure, mistake)
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melancholy(noun, depression, sadness, gloom, unhappiness)
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misanthropy
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miscalculation(noun, defeat, blow, failure, mistake)
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mischance(noun, defeat, blow, failure, mistake)
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mishap(noun, defeat, blow, failure, mistake)
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mistake(noun, defeat, blow, failure, disaster)
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mortification(disappointment, letdown, disenchantment)
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need(noun, depression, sadness, gloom, unhappiness)
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nonfulfillment(hindrance, disappointment, annoyance, prevention, blocking)
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nonsuccess(hindrance, disappointment, annoyance, letdown, prevention)
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object
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obstacle(noun, defeat, blow, failure, mistake)
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obstruction(hindrance, disappointment, annoyance, prevention, blocking)
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odium
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ordeal(noun, depression, sadness, gloom, unhappiness)
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pain(noun, depression, sadness, gloom, unhappiness)
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painfulness
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pang(noun, depression, sadness, gloom, unhappiness)
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penury(noun, depression, sadness, gloom, unhappiness)
11 years ago|1k views|share |citing 
APASmart Define. (2015). bitter pill thesaurus. Retrieved September 26, 2026, from https://smartdefine.org/bitter_pill/thesaurus/synonyms
ChicagoSmart Define. 2015. "bitter pill thesaurus" https://smartdefine.org/bitter_pill/thesaurus/synonyms (accessed September 26, 2026).
HarvardSmart Define 2015, bitter pill thesaurus, Smart Define, viewed 26 September, 2026, <https://smartdefine.org/bitter_pill/thesaurus/synonyms>.
MLASmart Define. "bitter pill thesaurus" 10 April 2015. Web. 26 September 2026. <https://smartdefine.org/bitter_pill/thesaurus/synonyms>