| toxin(noun, difficulty, hardship, perplexity) |
| venom(noun, damage, evil, harm) |
| vitiate(verb, honor, damage, harm, clean) |
| worsen(verb, break, hurt, damage, harm) |
| blockage(noun, difficulty, injury, obstacle, impediment) |
| hindrance(noun, difficulty, injury, obstacle, impediment) |
| obstruction(noun, difficulty, injury, obstacle, impediment) |
| pestilence(noun, difficulty, hardship, perplexity) |
| relapse(verb, damage, harm, disadvantage) |
| affliction(noun, difficulty, hardship, perplexity) |
| cancer(noun, difficulty, hardship, perplexity) |
| disorder(noun, difficulty, hardship, perplexity) |
| impairment(noun, difficulty, hardship, perplexity) |
| indisposition(noun, difficulty, hardship, perplexity) |
| infirmity(noun, difficulty, hardship, perplexity) |
| malady(noun, difficulty, hardship, perplexity) |
| puzzle(noun, difficulty, hardship, perplexity) |
| trauma(noun, difficulty, hardship, perplexity) |
| depress(verb, action, break, hurt, difficulty) |
| stop(noun, difficulty, injury, obstacle, impediment) |