| contretemps(noun, trouble, blow, burden, cross) |
| delinquency(noun, inexpedience, untimeliness) |
| discombobulate(verb, trouble, bother, disturb, disrupt) |
| evil(noun, weakness, negative, problem, disadvantage) |
| hardship(noun, trouble, blow, difficulty, distress) |
| impede(upset, bother, burden, obstruct, meddle) |
| imposition(noun, trouble, difficulty, weakness, bar) |
| ineptitude |
| ineptness(noun, inexpedience) |
| inexpediency |
| infliction(pain, irritation, annoyance) |
| intrusion |
| irritant(noun, trouble, strain, difficulty, pain) |
| liability(noun, trouble, difficulty, bar, burden) |
| load(noun, verb, trouble, bother, blow) |
| millstone(noun, trouble, worry, damage, anxiety) |
| nettle(verb, trouble, annoy, irritate, aggravate) |
| onus |
| peeve(verb, trouble, vex, displease) |
| perplex(verb, upset, trouble, hurt, bother) |