| care(noun, trouble, worry, concern, blow) |
| deprivation(noun, want, hardship, poverty, scarcity) |
| despondence(noun, melancholy, sadness, unhappiness, despair) |
| disease(noun, difficulty, burden, suffering, wickedness) |
| dissatisfaction(noun, activity, stop, action, upset) |
| downer(noun, trouble, worry, concern, difficulty) |
| dreariness(noun, trouble, worry, distress, sorrow) |
| ennui(noun, trouble, worry, distress, sorrow) |
| forlornness(noun, sorrow, depression, melancholy, unhappiness) |
| glumness(noun, melancholy, sadness, unhappiness, dejection) |
| grimness(noun, dejection) |
| indigence(noun, trouble, depression, sadness, gloom) |
| infliction(noun, pain, disaster, adversity, calamity) |
| irritation(noun, trouble, worry, concern, blow) |
| killjoy |
| miserableness(noun, sorrow, depression, melancholy, sadness) |
| scourge(noun, trouble, ruin, difficulty, distress) |
| rack(noun, distress, pain, torment, suffering) |
| bane(noun, trouble, blow, distress, care) |
| bitterness(noun, distress, pain, sorrow, depression) |