| vexed question(noun, trouble, challenge, question) |
| worriment(noun, trouble, concern, strain, difficulty) |
| Gordian knot(expression, trouble, difficulty, mess, puzzle) |
| adversity(noun, difficulty, distress, burden, depression) |
| affliction(noun, difficulty, distress, burden, depression) |
| aggravation(noun, trouble, bother, strain, difficulty) |
| anxiety(noun, trouble, worry, concern, strain) |
| assignment(noun, study, interest, issue, responsibility) |
| besetment(noun, trouble, bother, pain, irritation) |
| blemish(noun, weakness, failing, flaw, defect) |
| block(noun, worry, difficulty, anxiety, hindrance) |
| bore(noun, trouble, bother, pain, irritation) |
| box(noun, fix, difficulty, informal, issue) |
| caper |
| chore |
| condition(noun, illness, sickness, pattern) |
| crunch(noun, point, difficulty, issue, mess) |
| defection(noun, doubt, uncertainty, dissent, reservation) |
| deficiency(noun, trouble, difficulty, weakness, bar) |
| delay(noun, check, stay, difficulty, hindrance) |