11 entries under cause great distress topic. ×

44
unfortunately(adverb, regret, sadly, unhappily, alas)
9
lamentably(adverb, gloomily, miserably, unfortunately, by bad luck)
8
grievously(adverb, by bad luck)
6
woefully(adverb, with sadness)
4
deplorably
1
distressfully
1
distressingly
1
heartbreakingly
1
heartrendingly
1
tragical
1
tragically
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APASmart Define. (2015). regrettably thesaurus. Retrieved October 1, 2026, from https://smartdefine.org/regrettably/thesaurus/synonyms
ChicagoSmart Define. 2015. "regrettably thesaurus" https://smartdefine.org/regrettably/thesaurus/synonyms (accessed October 1, 2026).
HarvardSmart Define 2015, regrettably thesaurus, Smart Define, viewed 1 October, 2026, <https://smartdefine.org/regrettably/thesaurus/synonyms>.
MLASmart Define. "regrettably thesaurus" 14 April 2015. Web. 1 October 2026. <https://smartdefine.org/regrettably/thesaurus/synonyms>