| irritation(noun, trouble, blow, distress, care) |
| jam(noun, trouble, difficulty, situation, hardship) |
| jinx(noun, difficulty, situation, hardship, misfortune) |
| load(noun, trouble, force, blow, strain) |
| melancholy(noun, adjective, distress, depression, sadness) |
| need(noun, trouble, worry, difficulty, depression) |
| opposition |
| plight(difficulty, limit, burden, edge, suffering) |
| poison(noun, difficulty, informal, situation, hardship) |
| predicament(noun, trouble, difficulty, pain, struggle) |
| privation(noun, trouble, worry, difficulty, depression) |
| problem(noun, difficulty, distress, burden, depression) |
| rack |
| reversal(ruin, destruction, misfortune, downfall, ruination) |
| rigorousness(noun, difficulty, laboriousness, strenuousness) |
| rigour |
| ruin(hurt, damage, evil, harm, collapse) |
| severity(noun, difficulty) |
| straits(noun, trouble, difficulty, hardship, misfortune) |
| strenuousness(noun, trouble, difficulty, pain, struggle) |