3
bitter cup(noun, expression, unpleasant, unavoidable, bummer)
2
affliction(noun, depression, sadness, gloom, unhappiness)
2
burden(noun, depression, sadness, gloom, unhappiness)
2
cross
2
curse(noun, depression, sadness, gloom, unhappiness)
2
distress(noun, depression, sadness, gloom, disappointment)
2
frustration(noun, hindrance, disappointment, letdown, prevention)
2
grievance(hindrance, disappointment, annoyance, prevention, blocking)
2
load(noun, depression, sadness, gloom, unhappiness)
2
sorrow(noun, depression, sadness, gloom, unhappiness)
2
trouble(noun, depression, sadness, gloom, unhappiness)
2
woe(noun, depression, sadness, gloom, unhappiness)
1
acerbity
1
acridity
1
acridness
1
astringence
1
astringency
1
bad part(noun, expression, unpleasant, unavoidable, bummer)
1
bitter draft
1
bitter draught
<1234510>
11 years ago|1k views|share |citing 
APASmart Define. (2015). bitter pill thesaurus. Retrieved September 21, 2026, from https://smartdefine.org/bitter_pill/thesaurus/synonyms
ChicagoSmart Define. 2015. "bitter pill thesaurus" https://smartdefine.org/bitter_pill/thesaurus/synonyms (accessed September 21, 2026).
HarvardSmart Define 2015, bitter pill thesaurus, Smart Define, viewed 21 September, 2026, <https://smartdefine.org/bitter_pill/thesaurus/synonyms>.
MLASmart Define. "bitter pill thesaurus" 10 April 2015. Web. 21 September 2026. <https://smartdefine.org/bitter_pill/thesaurus/synonyms>