What is the meaning of deranged?

verb

• Derange mentally, throw out of mental balance; make insane.
  • usage: "The death of his parents unbalanced him"
  • synonyms: unbalance, derange
• Throw into great confusion or disorder.
  • usage: "Fundamental Islamicists threaten to perturb the social order in Algeria and Egypt"
  • synonyms: perturb, derange, throw out of kilter

adjective

• Driven insane.
  • synonyms: crazed, half-crazed