| dope |
| hardship(noun, trouble, difficulty, distress, shock) |
| heartbreak(noun, pain, sorrow, depression, melancholy) |
| hypnotic |
| misery(noun, trouble, worry, concern, difficulty) |
| misfortune(noun, trouble, defeat, blow, difficulty) |
| pain(noun, bother, distress, trial, suffering) |
| tranquillizer |
| woe(noun, distress, shock, pain, struggle) |
| adversity(noun, trouble, difficulty, distress, shock) |
| annoyance(hindrance, disappointment, nuisance, prevention, blocking) |
| bad luck(noun, expression, trouble, difficulty, distress) |
| barbiturate |
| calamity(noun, trouble, defeat, blow, difficulty) |
| catastrophe(noun, trouble, difficulty, shock, pain) |
| difficulty(noun, trouble, distress, situation, trial) |
| disaster(noun, trouble, defeat, blow, difficulty) |
| dismay(noun, feeling, distress, shock, disappointment) |
| grief(noun, distress, pain, sorrow, depression) |
| lower |