2
sorrow(noun, trouble, difficulty, distress, depression)
2
suffering(noun, trouble, worry, concern, difficulty)
2
tension(noun, trouble, worry, concern, doubt)
2
torture(noun, pain, sufferings)
2
tranquilizer(noun, drug, dope, merchandise, sedative)
2
upper
2
vexation(hindrance, trial, disappointment, annoyance, suffering)
2
vicissitude(noun, trouble, difficulty, drag, hardship)
2
wet blanket(noun, expression, idiom, person, bother)
2
worriment(noun, trouble, worry, concern, anxiety)
2
worry(noun, trouble, concern, distress, anxiety)
1
adverse circumstances
1
aggravation
1
agitation(noun, anxiety, shock, alarm, disappointment)
1
alarm(noun, anxiety, shock, disappointment, apprehension)
1
alcohol
1
all-overs(noun, trouble, worry, concern, anxiety)
1
amobarbital sodium
1
angst(noun, trouble, worry, concern, anxiety)
1
antidepressant
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APASmart Define. (2016). downer thesaurus. Retrieved September 23, 2026, from https://smartdefine.org/downer/thesaurus/synonyms
ChicagoSmart Define. 2016. "downer thesaurus" https://smartdefine.org/downer/thesaurus/synonyms (accessed September 23, 2026).
HarvardSmart Define 2016, downer thesaurus, Smart Define, viewed 23 September, 2026, <https://smartdefine.org/downer/thesaurus/synonyms>.
MLASmart Define. "downer thesaurus" 1 April 2016. Web. 23 September 2026. <https://smartdefine.org/downer/thesaurus/synonyms>