| dejection(noun, trouble, worry, distress, care) |
| destitution(noun, trouble, worry, difficulty, depression) |
| destruction(trouble, hurt, ruin, damage, harm) |
| detriment(noun, cut, hurt, wrong, damage) |
| difficulties |
| disappointment(noun, upset, trouble, worry, concern) |
| discipline(noun, trouble, force, strain, difficulty) |
| disquiet(noun, trouble, worry, strain, anxiety) |
| doom(noun, ruin, slip, shock, collapse) |
| downer(difficulty, shock, failure, disaster, trial) |
| encumbrance(noun, trouble, charge, worry, concern) |
| endemic(disorder, illness, defect, sickness, ailment) |
| epidemic(noun, disorder, condition, cold, illness) |
| excruciation(noun, distress, pain, torment, misery) |
| execution(noun, punishment, torture, death, killing) |
| failure(noun, upset, trouble, ruin, blow) |
| fever(noun, hurt, disorder, distress, pain) |
| gall and wormwood(expression, idiom) |
| gloom(noun, trouble, worry, distress, pain) |
| hard knocks(expression, trouble, difficulty, shock, failure) |