| medical disorder(noun, weak, disorder, disease, ill) |
| melancholy(noun, trouble, worry, distress, pain) |
| painfulness(noun, pain, adversity) |
| pathological disease(noun, weak, disorder, disease, ill) |
| penalty(noun, punishment, plague, blight) |
| rue(noun, trouble, worry, distress, pain) |
| ruin(noun, trouble, hurt, wrong, damage) |
| sore(noun, adjective, cut, hurt, wrong) |
| sting(noun, cut, hurt, wrong, damage) |
| thorn(noun, trouble, blow, distress, care) |
| throb(noun, hurt, distress, pain, tenderness) |
| travail(noun, trouble, worry, difficulty, lack) |
| virus(disorder, disease, collapse, disturbance, illness) |
| weight(noun, trouble, force, strain, difficulty) |
| accident(noun, trouble, hurt, ruin, worry) |
| afflict(noun, verb, pain) |
| albatross(noun, trouble, worry, concern, blow) |
| bad news(noun, expression, trouble, ruin, worry) |
| bitter draught(expression, idiom, pain) |
| bitterness(noun, worry, concern, distress, pain) |