| frustration(noun, difficulty, pain, stress, irritation) |
| grief(noun, trouble, worry, passion, distress) |
| hangover(noun, result) |
| headaches |
| hindrance(noun, trouble, difficulty, pain, mess) |
| infliction(noun, pain, irritation, annoyance) |
| job(noun, duty, commission, mission, chore) |
| lookout |
| millstone(noun, business, work, burden, heavy) |
| molestation(trouble, strain, difficulty, problem, aggravation) |
| neuralgia |
| odontalgia |
| onerous(adjective, difficult, heavy, cruel, arduous) |
| oppressive(adjective, severe, harsh, heavy, cruel) |
| otalgia |
| pang(noun, trouble, worry, passion, care) |
| persecution(reverse, trial, suffering, misfortune, heartache) |
| pill(noun, bother, pain, irritation, annoyance) |
| predicament(noun, trouble, dispute, difficulty, pain) |
| quagmire(noun, trouble, difficulty, pain, mess) |