| serious problem(expression, state, situation, status) |
| breakdown(noun, disorder, disease, collapse, disturbance) |
| defect(noun, upset, disorder, weakness, condition) |
| handicap(noun, health, disease, difficulty, situation) |
| hitch(noun, place, position, situation, troubles) |
| hurt(noun, trouble, evil, harm, distress) |
| issue(noun, place, position, situation, troubles) |
| mess(noun, place, position, situation, troubles) |
| obstacle(noun, place, position, situation, troubles) |
| suffering(noun, weak, disorder, disease, ill) |
| worry(noun, trouble, place, defeat, position) |
| affection(noun, weak, disorder, disease, ill) |
| symptom(noun, health, disease, difficulty, situation) |
| difficult situation(noun, expression, place, position, situation) |
| abnormality(noun, disorder, sick, sickness) |
| blast(noun, weak, disorder, disease, ill) |
| collapse(noun, disorder, disease, disturbance, illness) |
| decrepitude(noun, disorder, disease, weakness, fault) |
| drawback(noun, place, position, situation) |
| setback(noun, place, defeat, position, situation) |