| provoking(adjective, hard, severe, pain, offensive) |
| rough(adjective, hard, tough, severe, nasty) |
| throbbing(adjective, painful, sickness, ache, anguishes) |
| troublous(adjective, hard, severe, happy, pain) |
| ugly(adjective, hard, severe, evil, rough) |
| uphill(adjective, tough, severe, difficult, awkward) |
| strenuous(adjective, tough, severe, difficult, awkward) |
| adverse(adjective, difficult, unpleasant, negative, critical) |
| awful(adjective, sickness, ache, anguishes) |
| caustic(adjective, sickness, ache, anguishes) |
| chafing(adjective, painful) |
| complex(adjective, hard, fancy, difficult, delicate) |
| complicated(adjective, hard, severe, rough, difficult) |
| galling(adjective, pain) |
| grueling(adjective, hard, tough, severe, difficult) |
| harrowing(adjective, tender, offensive, raw, painful) |
| importunate(adjective, demanding, insistent, bothersome, worrisome) |
| incommodious(adjective, offensive, comfort, awkward, uncomfortable) |
| mean(adjective, hard, easy, slang, rough) |
| operose(adjective, tough, severe, difficulty, difficult) |