| tiresome(adjective, hard, tough, severe, pain) |
| disturbing(adjective, hard, happy, difficult, pain) |
| grievous(adjective, hard, tough, severe, rough) |
| uncomfortable(adjective, rough, painful, sickness, ache) |
| vexing(adjective, hard, delicate, complex, irritating) |
| distressful(adjective, happy, pain, painful, adverse) |
| inconvenient(adjective, offensive, comfort, uncomfortable, unacceptable) |
| severe(adjective, hard, tough, difficult, tender) |
| sore(adjective, painful, sickness, ache, anguishes) |
| toilsome(adjective, hard, tough, severe, difficulty) |
| tormenting(adjective, painful, sickness, ache, anguishes) |
| upsetting(adjective, hard, tough, severe, happy) |
| worrisome(adjective, hard, severe, happy, pain) |
| agonizing(adjective, painful, sickness, ache, anguishes) |
| demanding(adjective, hard, tough, severe, difficult) |
| thorny(adjective, hard, rough, difficult, delicate) |
| time-consuming |
| tricky(adjective, hard, tough, difficult, complex) |
| worrying(adjective, hard, tough, severe, heavy) |
| aggravating(adjective, hard, severe, pain, offensive) |