What is the meaning of substance?

noun

• The real physical matter of which a person or thing consists.
  • usage: "DNA is the substance of our genes"
• The choicest or most essential or most vital part of some idea or experience.
  • usage: "the gist of the prosecutor's argument"; "the heart and soul of the Republican Party"; "the nub of the story"
  • synonyms: kernel, core, center, centre, essence, gist, heart, heart and soul, inwardness, marrow, meat, nub, pith, sum, nitty-gritty
• The idea that is intended.
  • usage: "What is the meaning of this proverb"
  • synonyms: meaning
• Material of a particular kind or constitution.
  • usage: "the immune response recognizes invading substances"
• Considerable capital (wealth or income. )
  • usage: "he is a man of means"
  • synonyms: means
• What a communication that is about something is about.
  • synonyms: message, content, subject matter
• A particular kind or species of matter with uniform properties.
  • usage: "shigella is one of the most toxic substances known to man"