| double whammy(noun, expression, pain, trial, suffering) |
| grievance(noun, trouble, worry, pain, sorrow) |
| hard luck(noun, expression, pain, disaster, trial) |
| headache(noun, trouble, distress, care, pain) |
| hurt(noun, torment, immorality, wickedness, evilness) |
| letdown(noun, pain, sorrow, depression, melancholy) |
| melancholy(noun, trouble, worry, distress, pain) |
| nightmare(noun, trouble, bother, blow, distress) |
| nuisance(noun, trouble, charge, bother, worry) |
| twinge(noun, trouble, care, pain, shame) |
| vexation(noun, trouble, charge, bother, worry) |
| Cancer(noun, magic, adversity, spell, affliction) |
| aggravation(noun, charge, worry, strain, anxiety) |
| angst(noun, pain, sorrow, torment, misery) |
| anxiety(noun, trouble, worry, blow, distress) |
| bemoaning(noun, trouble, worry, distress, pain) |
| blow(noun, trouble, worry, distress, care) |
| calvary(noun, trouble, bother, blow, distress) |
| casualty(noun, disaster, trial, adversity, calamity) |
| contretemps(noun, disaster, trial, adversity, calamity) |